About Tenpoint Therapeutics

Tenpoint Therapeutics is a global, commercial biotechnology company focused on developing groundbreaking treatments to improve vision in the aging eye. Our pipeline includes paradigm-shifting therapeutics for ophthalmic indications with significant unmet medical need, including presbyopia, cataracts, and geographic atrophy.

Our lead product, YUVEZZI™, is the first and only dual-agent eye drop for the treatment of presbyopia in adults and was approved by the FDA on January 28, 2026. Presbyopia, the gradual loss of near vision that typically begins around age 45, affects about two billion people globally and 128 million people in the U.S. YUVEZZI™ is now commercially available in the U.S.

Role Overview

We are seeking a Manager, Payroll & Benefits who can dive into the details while also shaping the big picture. You’ll ensure our employees across the U.S. (multi-state), U.K., and Switzerland are paid accurately and on time, supported by robust benefits programs, and confident that their data is managed with integrity.

This role is both hands-on and strategic: you’ll run payroll, administer benefits, and manage HRIS data while also designing scalable processes, anticipating the needs of a growing global workforce, and partnering with Finance, HR, and vendors to strengthen compliance and efficiency. You’ll also help ensure we remain audit-ready and well-prepared through commercial launch.

Key Responsibilities

Payroll Management (Operational + Strategic)

Run multi-state U.S. payroll and U.K. payroll directly through Rippling, ensuring accuracy, timeliness, and compliance across local, state, federal, and international regulations. Oversee Swiss payroll via a third-party vendor, ensuring service quality and preparing for eventual in-house transition. Reconcile payroll reports and prepare journal entries for Finance, ensuring accurate postings to the general ledger. Manage year-end payroll activities (W-2s, P60s, tax filings, and other statutory reports), including the accurate treatment of vehicle allowances, stipends, and other taxable fringe benefits. Administer U.S. retirement plan contributions and U.K. pension fund allocations, ensuring accurate transfers, reconciliations, and compliance. Maintain workers’ compensation compliance, including proper state setup, reporting, employee classifications, and coordination of annual audits with carriers and brokers. Ensure I-9 employment verification compliance, including accurate documentation, timelyreverifications, and audit readiness. Proactively build processes to support payroll expansion into new geographies as we scale. Maintain audit-ready documentation and scalable practices.

Benefits Administration (Operational + Strategic)

Administer employee benefits in the U.S., U.K., and Switzerland, including health, dental, vision, life, disability, retirement/pension, and wellness programs. Partner with brokers and vendors to evaluate programs, recommend enhancements, and ensure offerings remain competitive and aligned with our culture. Provide responsive support for employee questions while also helping plan for the evolving needs of a global workforce. Ensure compliance with ERISA, ACA, GDPR, and other applicable frameworks

HRIS & Data Integrity

Maintain accurate employee records in Rippling, ensuring timely entry, compliance, and data integrity. Build and deliver reports and dashboards for HR, Finance, and leadership to support planning, audits, and decision-making. Partner with HR, Finance, and IT to maintain seamless data flows between systems andensure audit-ready reporting for compliance and regulatory compliance.

Process Improvement & Compliance

Identify opportunities to streamline and automate payroll and benefits operations forefficiency and employee experience. Develop scalable policies, documentation, and practices to support rapid growth and global expansion.Stay ahead of employment law and regulatory changes across all jurisdictions, ensuring compliance and readiness for future milestones such as commercial launch and IPO preparation. Collaborate cross-functionally with HR, Finance, IT, and Compliance to strengthen controls and reduce risk. Experience Prior experience running payroll for organizations of 200+ employees across multiple U.S. states is required. Strong knowledge of multi-state U.S. payroll and benefits; U.K. and/or Swiss payroll/benefits experience a plus. 5+ years of payroll and benefits experience, ideally with multi-country exposure. Hands-on experience with Rippling (or another HRIS/payroll system) and proven ability to maintain HRIS data integrity. Familiarity with journal entry preparation, payroll reconciliations, and retirement/pension administration. Experience ensuring audit readiness and supporting high-growth environments preparing for commercial scale-up. Knowledge of workers’ comp programs and I-9 verification compliance. Ability to balance day-to-day execution with strategic planning. Experience managing vendors and holding them accountable for service excellence. Strong analytical, organizational, and communication skills. Comfort working in a fast-paced, scaling, global environmentPhysical Requirements & Reasonable Accommodation

This role is primarily a desk-based job requiring the ability to operate a computer and communicate effectively in a remote work environment. The employee may be required to sit for extended periods, engage in video or phone meetings, and use standard office equipment. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of the role. If you need assistance and/or a reasonable accommodation during the interview process, please let our recruiting team know.   

Equal Opportunity Employer

We are an Equal Opportunity Employer. Consistent with applicable law, all qualified applicants will receive consideration for employment without regard to race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, Veteran status, or any other characteristic protected by applicable local laws, regulations and ordinances.

Salary and Benefits Information

We know our people are the driving force behind the success of our mission and vision. That’s why we offer a competitive benefit package to attract the very best talent to our team and to take care of our employees and their families. Below is a snapshot of our U.S. benefits package for full-time employees.

Generous medical, dental, and vision health insurance plans Flexible spending accounts for health and dependent care Short-term, long-term, and life/AD&D insurance Employee Assistance Program 20 paid vacation days, 12 paid holidays, and 12 sick days 401(k) Retirement Plan with 100% company match up to 4% and immediate vesting Hybrid work options Wellness Resources Stock Options

Salary Range: $120,000 to $140,000 USD per year

For more information, visit www.tenpointherapeutics.com and follow us on LinkedIn, X, and Instagram.

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